The pathology of Plasmodium chabaudi infection is not ameliorated by the secreted filarial nematode immunomodulatory molecule, ES-62

Authors: LAMB, T. J.¹; VOISINE, C.¹; KOERNIG, S.¹; EGAN, C. A.¹; HARNETT, W.²; LANGHORNE, J.¹

Source: Parasite Immunology, Volume 29, Number 5, May 2007 , pp. 271-276(6)

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Abstract:

SUMMARY

ES-62 is a phosphorylcholine-containing glycoprotein secreted by filarial nematodes. This molecule has been shown to reduce the severity of inflammation in collagen-induced arthritis (CIA) in mice, a model of rheumatoid arthritis, via down-regulation of anti-collagen type 1 immune responses. Malaria parasites induce a pro-inflammatory host immune response and many of the symptoms of malaria are immune system-mediated. Therefore we have asked whether the immunomodulatory properties of ES-62 can down-regulate the severity of malaria infection in BALB/c mice infected with Plasmodium chabaudi. We have found that ES-62 has no significant effect on the course of P. chabaudi parasitaemia, and does not significantly affect any of the measures of malaria-induced pathology taken throughout infection.

Keywords: BALB/c; ES-62; malaria; pathology; Plasmodium chabaudi

Document Type: Research article

DOI: http://dx.doi.org/10.1111/j.1365-3024.2007.00941.x

Affiliations: 1: Division of Parasitology, National Institute for Medical Research, The Ridgeway, Mill Hill, London NW7 1AA, UK, 2: Strathclyde Institute of Pharmacy and Biomedical Sciences, University of Strathclyde, 27 Taylor Street, Glasgow G4 0NR, UK

Publication date: 2007-05-01