Successful Topical Treatment of Sorafenib-Induced Hand-Foot Skin Reaction in a Child with Hepatocellular Carcinoma

Authors: HÜTTEN, MATTHIAS¹; LASSAY, LISA¹; SACHS, BERNHARDT²; DEUTZ, PETER¹; MERTENS, ROLAND¹; BARON, JENS MALTE³; MERK, HANS-FRIEDRICH³; OTT, HAGEN³

Source: Pediatric Dermatology, Volume 26, Number 3, May/June 2009 , pp. 349-350(2)

Publisher: Wiley-Blackwell

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Abstract:

Orally active kinase inhibitors such as Sorafenib are known to elicit cutaneous side effects in the majority of adult patients, whereas specific cutaneous complications of this agent have not been described in children so far. We here present the first pediatric case of Sorafenib-induced hand-foot-skin reaction and its successful topical therapy facilitating continuation of kinase inhibitor treatment.

Document Type: Research article

DOI: http://dx.doi.org/10.1111/j.1525-1470.2009.00933.x

Affiliations: 1: Departments of Pediatrics and Adolescent Medicine 2: Dermatology and Allergology, RWTH Aachen University Hospital, Aachen, Germany 3: Federal Institute for Drugs and Medical Devices, Bonn, Germany

Publication date: 2009-05-01