Successful Treatment of Severe Iatrogenic Calcinosis Cutis with Intravenous Sodium Thiosulfate in a Child Affected by T-Acute Lymphoblastic Leukemia

Authors: Raffaella, Colombatti¹; Annapaola, Calò¹; Tullio, Iacopetti²; Angelo, Rosolen¹; Giuseppe, Lombardi³; Simone, Cesaro¹

Source: Pediatric Dermatology, Volume 26, Number 3, May/June 2009 , pp. 311-315(5)

Publisher: Wiley-Blackwell

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Abstract:

Sodium thiosulfate has been successfully used to treat calcyphilaxis in adults and children, but its effect on iatrogenic calcinosis cutis secondary to extravasation of calcium solutions is less known. We describe a 5-year-old boy with acute lymphoblastic leukemia who developed severe calcinosis cutis in the right forearm and hand, and in the left leg and foot after extravasation of calcium gluconate during treatment for tumor-lysis-syndrome-related hypocalcaemia. Surgical debridement, local wound care, hyperbaric oxygen therapy, and sodium thiosulfate infusion achieved a complete healing of all lesions in an eight-month period with a short discontinuation of chemotherapy. No functional or sensitive impairment remained.

Document Type: Research article

DOI: http://dx.doi.org/10.1111/j.1525-1470.2008.00776.x

Affiliations: 1: Clinic of Pediatric Oncology-Hematology, Department of Pediatrics, University of Padova 2: Pediatric Plastic Surgery Unit, Azienda Ospedaliera of Padova 3: Veneto Institute of Oncology, Padova, Italy

Publication date: 2009-05-01