IngentaConnect 5 5-Fluorouracil Cream for Treatment of Verruca Vulgaris in Child...

Authors: Gladsjo, Julie Akiko¹; Alió Sáenz, Alessandra B.²; Bergman, James³; Kricorian, Greg⁴; Cunningham, Bari B.⁵

Source: Pediatric Dermatology, Volume 26, Number 3, May/June 2009 , pp. 279-285(7)

Abstract:

Warts are a common pediatric skin disease. Most treatments show only modest benefit, and some are poorly tolerated because of pain. 5-fluorouracil interferes with deoxyribonucleic acid and ribonucleic acid synthesis, and is used to treat genital warts in adults. Efficacy, safety, and tolerability of topical 5% 5-fluorouracil for treatment of common warts were examined in an open-label pilot study with pediatric patients. Thirty-nine children who have at least two hand warts applied 5% 5-fluorouracil cream (Efudex, Valeant Pharmaceuticals International) once or twice daily, under occlusion for 6 weeks. Assessment of treatment response and side effects was performed at baseline, treatment completion, and 3- and 6-month follow-ups. Hematology measures, liver function tests, and medication blood levels were reassessed at treatment completion. Eighty-eight percent of treated warts improved after 6 weeks of treatment, and 41% of subjects had complete resolution of at least one wart. Treatment response did not differ between once or twice daily applications. Tolerability and patient satisfaction were excellent. No subject had clinically significant blood levels of 5-fluorouracil. At 6 month follow-up, 87% of complete responders had no wart recurrence. Topical 5% 5-fluorouracil is a safe, effective, and well-tolerated treatment for warts in children.

Document Type: Research article

DOI: 10.1111/j.1525-1470.2008.00800.x

Affiliations: 1: University of California, San Diego, California 2: Rady Children's Hospital and Health Center, San Diego, California 3: Division of Dermatology, University of British Columbia, Vancouver, British Columbia 4: Valeant Pharmaceuticals International, Costa Mesa, California 5: Comprehensive Dermatology Group, Encinitas, California

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5% 5-Fluorouracil Cream for Treatment of Verruca Vulgaris in Children