Dactinomycin-Induced, Severe Lichenoid Eruption in a Child

Authors: Ridola, V.¹; Mahé, E.²; Fawaz, O.¹; Galmiche, L.³; Patte, C.¹; Grill, J.¹

Source: Pediatric Dermatology, Volume 23, Number 5, September/October 2006 , pp. 503-506(4)

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Abstract:

There is little information in the medical literature about skin rashes associated with dactinomycin in the absence of radiotherapy. We report a 12-month-old male child who developed a severe cutaneous reaction that consisted of a widespread pruritic papular eruption associated with fever and a poor general state after dactinomycin administration. Skin biopsy specimen findings confirmed the diagnosis of lichenoid eruption. The rash improved with topical steroid treatment and completely resolved within 1 month with persistence of a residual mild hyperpigmentation. Dactinomycin administration was discontinued for the remaining cycles of chemotherapy.

Document Type: Research article

DOI: http://dx.doi.org/10.1111/j.1525-1470.2006.00294.x

Affiliations: 1: Department of Pediatric Oncology, Gustave Roussy Institute, Villejuif 2: Department of Pediatric Dermatology, Necker-Enfants Malades Hospital, Paris 3: Department of Pathology, Necker-Enfants Malades Hospital, Paris, France

Publication date: 2006-09-01