Drug-induced Hypersensitivity Syndrome in a Premature Infant

Authors: Sule Yigit¹; Ayse Korkmaz¹; Bulent Sekerel²

Source: Pediatric Dermatology, Volume 22, Number 1, January 2005 , pp. 71-74(4)

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Abstract:

Fever, skin reactions, and limb edema because of drug-induced hypersensitivity have been reported in children because of various drugs, mainly aromatic antiepileptic drugs such as phenytoin, phenobarbital, carbamazepin, and primidone. The skin reactions differ in severity and range from mild maculopapular erythema to exfoliative dermatitis. They have been described in older children but have not been reported in newborn infants. We report a premature newborn infant who developed fever, skin reactions, and edema because of phenytoin while receiving anticonvulsant therapy.

Document Type: Research article

DOI: http://dx.doi.org/10.1111/j.1525-1470.2005.22116.x

Affiliations: 1: Department of Neonatology, Hacettepe University, Ihsan Dogramici Children's Hospital, Ankara, Turkey, and 2: Department of Pediatric Allergy, Hacettepe University, Ihsan Dogramici Children's Hospital, Ankara, Turkey

Publication date: 2005-01-01