Hyperperfusion in primary somatosensory region related to somatic hallucination in the elderly

Authors: Nemoto, Kiyotaka¹; Mizukami, Katsuyoshi¹; Hori, Takafumi¹; Tachikawa, Hirokazu¹; Ota, Miho¹; Takeda, Tohoru²; Ohnishi, Takashi³; Matsuda, Hiroshi⁴; Asada, Takashi¹

Source: Psychiatry and Clinical Neurosciences, Volume 64, Number 4, 1 August 2010 , pp. 421-425(5)

Publisher: Wiley-Blackwell

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Abstract:

Aim: The purpose of the present study was to investigate the regional cerebral blood flow (rCBF) of patients with delusional disorder, somatic type (DDST) exhibiting somatic hallucination.

Methods: Five patients diagnosed with DDST, as well as 20 control subjects, were examined. All subjects underwent technetium-99m ethyl cysteinate dimer brain perfusion single-photon emission computed tomography. Statistical analysis was performed with SPM5, using a two-sample t-test model to test the regional population effect on rCBF.

Results: Patients with DDST had a significant increase in perfusion in the left post-central gyrus and the right paracentral lobule, both of which are involved in somatic sensory processing.

Conclusion: Somatic hallucination might be associated with increased perfusion in the primary somatosensory regions.

Document Type: Research article

DOI: http://dx.doi.org/10.1111/j.1440-1819.2010.02101.x

Affiliations: 1: Departments of Psychiatry and 2: Radiology, Institute of Clinical Medicine, University of Tsukuba, Ibaraki, 3: Department of Psychosomatic Research, National Institute of Mental Health, National Center of Neurology and Psychiatry, Tokyo and 4: Department of Nuclear Medicine, Saitama Medical University International Medical Center, Saitama, Japan

Publication date: 2010-08-01