Effects of polydipsia-hyponatremia on seizures in patients with epilepsy

Authors: OKAZAKI, MITSUTOSHI; ITO, MASUMI¹; KATO, MASAAKI

Source: Psychiatry and Clinical Neurosciences, Volume 61, Number 3, June 2007 , pp. 330-332(3)

Publisher: Blackwell Publishing

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Abstract:

Aggravation of seizures due to hyponatremia was investigated in five patients with epilepsy and polydipsia-hyponatremia. They experienced marked increases in the frequency of their complex partial seizures with a decrease in the serum sodium level to 118-127 mEq/L. In all cases, the serum sodium level returned to normal through restriction of fluids, and the clinical seizures improved. All patients had shown intellectual impairment and/or psychotic episodes, and all had been given antipsychotics. Hyponatremia caused by polydipsia appears to be a risk factor for aggravation of habitual seizures in patients with epilepsy.

Keywords: antipsychotics; epilepsy; hyponatremia; polydipsia; seizure

Document Type: Short communication

DOI: 10.1111/j.1440-1819.2007.01663.x

Affiliations: 1: Tenshi Hospital, Sapporo, and

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