Effects of polydipsia-hyponatremia on seizures in patients with epilepsy

Abstract:

 

Aggravation of seizures due to hyponatremia was investigated in five patients with epilepsy and polydipsia-hyponatremia. They experienced marked increases in the frequency of their complex partial seizures with a decrease in the serum sodium level to 118-127 mEq/L. In all cases, the serum sodium level returned to normal through restriction of fluids, and the clinical seizures improved. All patients had shown intellectual impairment and/or psychotic episodes, and all had been given antipsychotics. Hyponatremia caused by polydipsia appears to be a risk factor for aggravation of habitual seizures in patients with epilepsy.

Keywords: antipsychotics; epilepsy; hyponatremia; polydipsia; seizure

Document Type: Short communication

DOI: 10.1111/j.1440-1819.2007.01663.x

Affiliations: 1: Tenshi Hospital, Sapporo, and