IngentaConnect Cerebellar volumes in men with schizophrenia and alcohol dependen...

Authors: VARNÄS, KATARINA; OKUGAWA, GAKU¹; HAMMARBERG, ANDERS²; NESVÅG, RAGNAR³; RIMOL, LARS M.⁴; FRANCK, JOHAN²; AGARTZ, INGRID

Source: Psychiatry and Clinical Neurosciences, Volume 61, Number 3, June 2007 , pp. 326-329(4)

Publisher: Blackwell Publishing

Abstract:

The aim of the present study was to investigate the variation in cerebellar morphology in schizophrenia and alcohol dependence. Volumetric measurements of cerebellar structures were performed using magnetic resonance imaging in 17 men with schizophrenia, nine men with alcohol dependence, and 18 healthy men. Schizophrenia patients had smaller volumes of the posterior superior vermis, while alcohol-dependent patients had smaller volumes of both the anterior and the posterior superior vermis compared with controls. The groups were not significantly different with respect to cerebellar hemisphere volumes. The results provide indications for differential morphological abnormalities of the cerebellar vermis in patients with schizophrenia and alcohol dependence.

Keywords: alcoholism; cerebellum; magnetic resonance imaging; psychotic disorders; schizophrenia

Document Type: Short communication

DOI: 10.1111/j.1440-1819.2007.01661.x

Affiliations: 1: Department of Neuropsychiatry, Kansai Medical University, Moriguchi, Japan, 2: Department of Clinical Neuroscience, Alcohol and Drug Addiction Research Section, Karolinska Institutet, Stockholm, Sweden and 3: Department of psychiatric research, Diakonhjemmet Hospital, Oslo, Norway 4: Institute of Psychiatry, University of Oslo, Oslo, Norway,

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Cerebellar volumes in men with schizophrenia and alcohol dependence