Association study of a functional promoter polymorphism of the X-box binding protein 1 gene in Japanese patients with schizophrenia

Authors: WATANABE, YUICHIRO¹; FUKUI, NAOKI¹; MURATAKE, TATSUYUKI; AMAGANE, HIDEKI¹; KANEKO, NAOSHI¹; NUNOKAWA, AYAKO¹; SOMEYA, TOSHIYUKI¹

Source: Psychiatry and Clinical Neurosciences, Volume 60, Number 5, October 2006 , pp. 633-635(3)

Publisher: Blackwell Publishing

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Abstract:

The functional promoter polymorphism −116C/G of the X-box binding protein 1 (XBP1) gene was found to be associated with schizophrenia in Han Chinese and Japanese subjects, although contradictive negative findings were also reported in European populations. To confirm this association in a Japanese population, the authors conducted a case-control association study. There was no significant difference in both genotype and allele frequencies between the patients and control subjects, suggesting that the XBP1 -116C/G polymorphism might not confer increased susceptibility for schizophrenia in a Japanese population. However, further studies using a larger sample with detailed clinical data should be performed in several populations.

Keywords: case-control study; schizophrenia; X-box binding protein 1 (XBP1)

Document Type: Short communication

DOI: 10.1111/j.1440-1819.2006.01570.x

Affiliations: 1: Department of Psychiatry, Niigata University Graduate School of Medical and Dental Sciences, Niigata, and

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