@article {SATO:October 2006:1323-1316:584, author = "SATO, SHINJI", author = "YAMAKAWA, YURIKO", author = "TERASHIMA, YASUSHI", author = "OHTA, HITOSHI", author = "ASADA, TAKASHI", title = "Efficacy of milnacipran on cognitive dysfunction with post-stroke depression: Preliminary open-label study", journal = "Psychiatry and Clinical Neurosciences", volume = "60", year = "October 2006", abstract = " 

The aim of this study was to assess the therapeutic efficacy of the serotonin norepinephrine reuptake inhibitor (SNRI), milnacipran, on both cognitive impairment and depression in post-stroke depression (PSD) patients. A total of 18 PSD patients, approximately 3 months after stroke, were divided into two groups, milnacipran and control. A total of 10 patients were assigned to the milnaciprane group and eight were assigned to control group. Their cognitive impairment and mood symptoms were measured using the Mini-Mental State Examination (MMSE) and Hamilton Depression Rating Scale (HAM-D) both at the time of admission and at discharge, an interval of approximately 3 months. This study examined the changes in both MMSE and HAM-D scores during the study period. A significant time-by-group interaction for results of the MMSE was observed, although there was no significant difference between the two groups on the HAM-D. Amelioration of cognitive impairment was greater in the milnacipran group than the control group. For PSD patients, milnacipran is effective in improving cognitive dysfunction.", pages = "584-589(6)", url = "http://www.ingentaconnect.com/content/bsc/pcn/2006/00000060/00000005/art00009" doi = "doi:10.1111/j.1440-1819.2006.01562.x" }