Effect of clonazepam treatment on antipsychotic drug-induced Meige syndrome and changes in plasma levels of GABA, HVA, and MHPG during treatment

Authors: Yoshimura, Reiji; Kakihara, Shingo; Soya, Atsushi; Ueda, Nobuhisa; Shinkai, Koji; Nakamura, Jun

Source: Psychiatry and Clinical Neurosciences, Volume 55, Number 5, October 2001 , pp. 543-546(4)

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Abstract:

We demonstrated the effect of clonazepam (2 mg/day) on Meige syndrome in two schizophrenic patients under continuous treatment with antipsychotic drugs, and changes in the plasma levels of γ-aminobutyric acid (GABA), homovanillic acid (HVA), and 3-methoxy-4-hydroxyphenylglycol (MHPG) in these cases. The plasma levels of HVA and MHPG during treatment with clonazepam were decreased in the responder, while not changed in the non-responder to clonazepam. A difference between the responder and the non-responder was not found in the plasma GABA levels. These results suggest that hyperactivities of the central dopaminergic and noradrenergic neurones are involved in the pathophysiology of Meige syndrome.

Keywords: antipsychotic drugs; γ-aminobutyric acid; homovanillic acid; Meige syndrome; 3-methoxy-4-hydroxyphenylglycol

Document Type: Short communication

Affiliations: 1: Department of Psychiatry, School of Medicine, University of Occupational and Environmental Health, School of Medicine, Fukuoka, Japan

Publication date: 2001-10-01