Effect of trazodone in a single dose before bedtime for sleep disorders accompanied by a depressive state: Dose-finding study with no concomitant use of hypnotic agent

Authors: Mashiko, Hirobumi¹; Niwa, Shin-Ichi¹; Kumashiro, Hisashi²; Kaneko, Yoshihiro³; Suzuki, Satoru⁴; Numata, Yoshihiko⁵; Horikoshi, Ryu⁶; Watanabe, Yoshinori⁷

Source: Psychiatry and Clinical Neurosciences, Volume 53, Number 2, April 1999 , pp. 193-194(2)

Publisher: Wiley-Blackwell

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Abstract:

This was the first dose-finding study of trazodone that was designed to be free of the concomitant use of hypnotics, in which the drug was administered in a single dose for sleep disorders combined with a depressive state. As a result, trazodone at the dosage of 50-100 mg/day improved sleep disorders, particularly at the 100 mg/day dosage. It was confirmed that trazodone improved sleep disorders combined with a depressive state when it was administered in a single dose before bedtime with no concomitant hypnotics.

Keywords: benzodiazepines; depression; single dose; sleep; trazodone

Document Type: Research article

DOI: http://dx.doi.org/10.1046/j.1440-1819.1999.00532.x

Affiliations: 1: Department of Neuropsychiatry, School of Medicine, Fukushima Medical University, Fukushima, 2: Shirakawa Kosei General Hospital, Shirakawa, 3: Maikohama Hospital, Iwaki, 4: Prefectural Aizu General Hospital, Aizuwakamatsu, 5: Fukushima Red Cross Hospital, Fukushima, 6: Horikoshi Psychosomatic Clinic, Fukushima, 7: Nanko Hospital, Shirakawa, Japan