Effects of trazodone on polysomnography, blood concentration and core body temperature in healthy volunteers

Authors: Yamadera, Hiroshi; Suzuki, Hideaki; Nakamura, Shuichi; Endo, Shunkichi

Source: Psychiatry and Clinical Neurosciences, Volume 53, Number 2, April 1999 , pp. 189-191(3)

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Abstract:

Polysomnography, blood concentration and core body temperature recordings were performed on 12 healthy volunteers with administration of trazodone and placebo. Trazodone increased slow wave sleep (SWS), and decreased the average, the highest and lowest core body temperature significantly compared to placebo. The blood concentration of trazodone correlated positively with amplitude (the difference between the highest and lowest temperature) and %SWS during the first period of a sleep phase divided into three periods, and negatively with the lowest temperature. The appearance time of the lowest temperature correlated negatively with %SWS.

Keywords: blood concentration; body core temperature; healthy volunteer; slow wave sleep; trazodone

Document Type: Research article

DOI: http://dx.doi.org/10.1046/j.1440-1819.1999.00531.x

Publication date: 1999-04-01