Sleep disordered breathing - a new component of syndrome x?

Authors: Coughlin, S.¹; Calverley, P.²; Wilding, J.¹

Source: Obesity Reviews, Volume 2, Number 4, 1 November 2001 , pp. 267-274(8)

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Abstract:

Sleep disordered breathing (SDB) is a complication of obesity estimated to occur in about 4-6% of overweight individuals. These respiratory disturbances during sleep incorporate a number of conditions including snoring, upper airway resistance syndrome and obstructive sleep apnoea syndrome (OSAS). It is thought that as well as having deleterious effects on sleep quality these conditions may also promote cardiovascular and hormonal changes leading to an elevated blood pressure and an increased incidence of cardiovascular morbidity. Evidence reviewed here points to an alteration in sympathovagal balance, baroreceptor sensitivity, insulin resistance and leptin, growth hormone and lipid levels. Whether these changes are a consequence of the associated obesity or the SDB itself remains to be proven.

Keywords: Sleep disordered breathing; obstructive sleep apnoea syndrome; snoring

Document Type: Research article

Affiliations: 1: Diabetes and Endocrinology Research Group, Department of Medicine, Clinical Sciences Centre, University Hospital Aintree, Longmoor Lane, Liverpool L9 7AL, UK; 2: Professor of Medicine, Pulmonary and Rehabilitation Research Group, Clinical Sciences Centre, University Hospital Aintree, Longmoor Lane, Liverpool L9 7AL, UK

Publication date: 2001-11-01