The impact of insulin resistance on woman's health and potential treatment options
Source: Annals of the New York Academy of Sciences, Volume 1205, Number 1, September 2010 , pp. 156-165(10)
Abstract:Insulin resistance (IR) is causatively related to metabolic syndrome and type 2 diabetes, both of which increase the risk of adverse cardiovascular events; in women in particular, severe IR affects the reproductive system causing subfertility and health problems to the mother and the fetus. To date lifestyle modification is the mainstay of treatment, whereas antiobesity drugs and bariatric surgery have been shown to improve insulin sensitivity and many surrogate metabolic defects, real reduction in cardiovascular endpoints has yet to be proved. Increasing attention is being directed to the role of the central nervous system in the modulation of IR, as well as to the use of recombinant adipocytokines for IR management. The scope of this article is to cast light on the detrimental effects of IR on metabolism and the body systems in women as well as to highlight the current therapeutic approach, drugs in progress, and future therapeutic perspectives.
Document Type: Research Article
Affiliations: 1: Warwickshire Institute for the Study of Diabetes, Endocrinology and Metabolism (WISDEM), University Hospital Coventry and Warwick Medical School, Coventry, UK. 2: Endocrine Unit, Second Department of Obstetrics and Gynaecology, Aretaieion University Hospital, Athens Medical School, Athens, Greece
Publication date: 2010-09-01