Annals of the New York Academy of Sciences

Preface
pp. xi-xii(2)

A Mitochondrial Etiology of Neurodegenerative Diseases: Evidence from Parkinson's Disease
pp. 1-20(20)
Authors: Khusnutdinova, Elza; Gilyazova, Irina; Ruiz-Pesini, Eduardo; Derbeneva, Olga; Khusainova, Rita; Khidiyatova, Irina; Magzhanov, Rim; Wallace, Douglas C.

Mitochondrial DNA Mutations in Disease, Aging, and Neurodegeneration
pp. 21-29(9)
Authors: Reeve, Amy K.; Krishnan, Kim J.; Turnbull, Doug

What Have PINK1 and HtrA2 Genes Told Us about the Role of Mitochondria in Parkinson's Disease?
pp. 30-36(7)
Authors: Plun-Favreau, Helene; Gandhi, Sonia; Wood-Kaczmar, Alison; Deas, Emma; Yao, Zhi; Wood, Nicholas W.

The Role of Mitochondria in Reactive Oxygen Species Metabolism and Signaling
pp. 37-52(16)
Author: Starkov, Anatoly A.

Oxidative Stress and Energy Crises in Neuronal Dysfunction
pp. 53-60(8)
Author: Nicholls, David G.

The Nrf2-ARE Pathway: An Indicator and Modulator of Oxidative Stress in Neurodegeneration
pp. 61-69(9)
Authors: Johnson, Jeffrey A.; Johnson, Delinda A.; Kraft, Andrew D.; Calkins, Marcus J.; Jakel, Rebekah J.; Vargas, Marcelo R.; Chen, Pei-Chun

Evidence of Oxidative Stress in Alzheimer's Disease Brain and Antioxidant Therapy: Lights and Shadows
pp. 70-78(9)
Authors: Praticò, Domenico

Evidence of Oxidant Damage in Huntington's Disease: Translational Strategies Using Antioxidants
pp. 79-92(14)
Authors: Stack, Edward C.; Matson, Wayne R.; Ferrante, Robert J.

Oxidative Stress in Parkinson's Disease: A Mechanism of Pathogenic and Therapeutic Significance
pp. 93-104(12)
Authors: Zhou, Chun; Huang, Yong; Przedborski, Serge

Mitochondria-Targeted Antioxidants in the Treatment of Disease
pp. 105-111(7)
Authors: Smith, Robin A.J.; Adlam, Victoria J.; Blaikie, Frances H.; Manas, Abdul-Rahman B.; Porteous, Carolyn M.; James, Andrew M.; Ross, Meredith F.; Logan, Angela; Cochemé, Helena M.; Trnka, Jan; Prime, Tracy A.; Abakumova, Irina; Jones, Bruce A.; Filipovska, Aleksandra; Murphy, Michael P.

Development of Mitochondria-targeted Aromatic-cationic Peptides for Neurodegenerative Diseases
pp. 112-121(10)
Author: Szeto, Hazel H.

A New Approach to Treating Alzheimer's Disease
pp. 122-128(7)
Author: Blass, John P.

Postischemic Oxidative Stress Promotes Mitochondrial Metabolic Failure in Neurons and Astrocytes
pp. 129-138(10)
Authors: Fiskum, Gary; Danilov, Camelia A.; Mehrabian, Zara; Bambrick, Linda L.; Kristian, Tibor; McKenna, Mary C.; Hopkins, Irene; Richards, E. M.; Rosenthal, Robert E.

Imaging Brain Activation: Simple Pictures of Complex Biology
pp. 139-170(32)
Authors: Dienel, Gerald A.; Cruz, Nancy F.

Structural Diversity of Mitochondria: Functional Implications
pp. 171-179(9)
Author: Mannella, Carmen A.

Brain Glucose Hypometabolism and Oxidative Stress in Preclinical Alzheimer's Disease
pp. 180-195(16)
Authors: Mosconi, Lisa; Pupi, Alberto; De Leon, Mony J.

Complexity and Heterogeneity: What Drives the Ever-changing Brain in Huntington's Disease?
pp. 196-205(10)
Authors: Rosas, H. Diana; Salat, David H.; Lee, Stephanie Y.; Zaleta, Alexandra K.; Hevelone, Nathanael; Hersch, Steven M.

Multinuclear Magnetic Resonance Spectroscopy for in Vivo Assessment of Mitochondrial Dysfunction in Parkinson's Disease
pp. 206-220(15)
Authors: Henchcliffe, Claire; Shungu, Dikoma C.; Mao, Xiangling; Huang, Chaorui; Nirenberg, Melissa J.; Jenkins, Bruce G.; Beal, M. Flint

Oxidant-induced Changes in Mitochondria and Calcium Dynamics in the Pathophysiology of Alzheimer's Disease
pp. 221-232(12)
Authors: Gibson, Gary E.; Karuppagounder, Saravanan S.; Shi, Qingli

Mitochondrial and Nuclear Cross Talk in Cell Death: Parthanatos
pp. 233-241(9)
Authors: Andrabi, Shaida A.; Dawson, Ted M.; Dawson, Valina L.

Role of the Ubiquitin Conjugation System in the Maintenance of Mitochondrial Homeostasis
pp. 242-253(12)
Authors: Neutzner, Albert; Benard, Giovanni; Youle, Richard J.; Karbowski, Mariusz

Developmental Restructuring of the Creatine Kinase System Integrates Mitochondrial Energetics with Stem Cell Cardiogenesis
pp. 254-263(10)
Authors: Chung, Susan; Dzeja, Petras P.; Faustino, Randolph S.; Terzic, Andre

The Mitochondrial Antioxidants MitoE₂ and MitoQ₁₀ Increase Mitochondrial Ca²⁺ Load upon Cell Stimulation by Inhibiting Ca²⁺ Efflux from the Organelle
pp. 264-274(11)
Authors: Leo, Sara; Szabadkai, György; Rizzuto, Rosario

Preventing NAD⁺ Depletion Protects Neurons against Excitotoxicity: Bioenergetic Effects of Mild Mitochondrial Uncoupling and Caloric Restriction
pp. 275-282(8)
Authors: Liu, Dong; Pitta, Michael; Mattson, Mark P.

Impairing the Mitochondrial Fission and Fusion Balance: A New Mechanism of Neurodegeneration
pp. 283-292(10)
Authors: Knott, Andrew B.; Bossy-Wetzel, Ella

The Disulfide Relay of the Intermembrane Space of Mitochondria: An Oxygen-Sensing System?
pp. 293-302(10)
Authors: Bihlmaier, Karl; Mesecke, Nikola; Kloeppel, Christine; Herrmann, Johannes M.

Dysfunction of Mitochondria and Sarcoplasmic Reticulum in the Pathogenesis of Collagen VI Muscular Dystrophies
pp. 303-311(9)
Authors: Bernardi, Paolo; Bonaldo, Paolo

Mitochondria and Hypoxia-induced Gene Expression Mediated by Hypoxia-inducible Factors
pp. 312-320(9)
Authors: Chavez, Angela; Miranda, Luis F.; Pichiule, Paola; Chavez, Juan C.

Nuclear Control of Respiratory Chain Expression by Nuclear Respiratory Factors and PGC-1-Related Coactivator
pp. 321-334(14)
Author: Scarpulla, Richard C.

Regulation of Forkhead Transcription Factor FoxO3a Contributes to Calorie Restriction-induced Prevention of Alzheimer's Disease-type Amyloid Neuropathology and Spatial Memory Deterioration
pp. 335-347(13)
Authors: Qin, Weiping; Zhao, Wei; Ho, Lap; Wang, Jun; Walsh, Kenneth; Gandy, Sam; Pasinetti, Giulio Maria

Screening for the Metabolic Basis of Neurodegeneration: Developing a Focused Proteomic Approach
pp. 348-357(10)
Authors: Murray, James; Capaldi, Roderick A.

Mitochondria and Huntington's Disease Pathogenesis: Insight from Genetic and Chemical Models
pp. 358-382(25)
Author: Browne, Susan E.

Small Molecule Activation of Adaptive Gene Expression: Tilorone or Its Analogs Are Novel Potent Activators of Hypoxia Inducible Factor-1 That Provide Prophylaxis against Stroke and Spinal Cord Injury
pp. 383-394(12)
Authors: Ratan, Rajiv R.; Siddiq, Ambreena; Aminova, Leila; Langley, Brett; McConoughey, Stephen; Karpisheva, Ksenia; Lee, Hsin-Hwa; Carmichael, Thomas; Kornblum, Harley; Coppola, Giovanni; Geschwind, Daniel H.; Hoke, Ahmet; Smirnova, Natalya; Rink, Cameron; Roy, Sashwati; Sen, Chandan; Beattie, Michael S.; Hart, Ron P.; Grumet, Martin; Sun, Dongming; Freeman, Robert S.; Semenza, Gregg L.; Gazaryan, Irina

Mitochondrial Approaches for Neuroprotection
pp. 395-412(18)
Authors: Chaturvedi, Rajnish K.; Beal, M. Flint

Index of Contributors
pp. 413-414(2)