N^ɛ-(Carboxymethyl)lysine during the Early Development of Hypertension

Authors: Baumann, Marcus; Stehouwer, Coen¹; Scheijen, Jean¹; Heemann, Uwe²; Struijker Boudier, Harry³; Schalkwijk, Casper¹

Source: Annals of the New York Academy of Sciences, Volume 1126, Number 1, April 2008 , pp. 201-204(4)

Publisher: Wiley-Blackwell

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Abstract:

Advanced glycation end products (AGEs) are associated with hypertension. Whether N^ɛ-(carboxymethyl)lysine (CML) contributes to the development of hypertension in young spontaneously hypertensive rats (SHR) remains to be established compared to WKY. We determined blood pressure, renal function, marker for oxidative stress (OS), and CML in young WKY rats and SHR. We found blood pressure was increased in SHR with no difference in renal function and OS compared to WKY. CML was elevated in plasma (2.3 ± 0.3 vs. 1.3 ± 0.2 μmol/L) and kidney (1.0 ± 0.1 vs. 0.5 ± 0.1 μmol/L) compared to WKY. Early CML accumulation may contribute to the development of hypertension potentially by inducing early renal inflammation independent of glomerular dysfunction or oxidative stress.

Keywords: Nɛ-(carboxymethyl)lysine; hypertension; spontaneously hypertensive rat; renal function; oxidative stress

Document Type: Research article

DOI: http://dx.doi.org/10.1196/annals.1433.004

Affiliations: 1: Department of Nephrology, Klinikum rechts der Isar, Technical University Munich, Munich, Germany 2: Department of Internal Medicine, Division of General Internal Medicine, University Hospital Maastricht, Maastricht, the Netherlands 3: Department of Pharmacology and Toxicology, University Maastricht, Maastricht, the Netherlands

Publication date: 2008-04-01