SLAM-Associated Protein Solves a Mystery of Autoimmunity

Authors: SAWADA, SHIGEMASA¹; TAKEI, MASAMI²; ISHIWATA, TETSUYOSI³; SHIRAIWA, HIDETAKA²; INOMATA, HIROTAKE¹; NOZAKI, TAKAMASA¹

Source: Annals of the New York Academy of Sciences, Volume 1109, Number 1, August 2007 , pp. 19-30(12)

Publisher: Wiley-Blackwell

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Abstract:

SLAM-associated protein (SAP) is essential for viral protection, lifelong immune memory (vaccination), and lifelong autoantibody production. We discuss how SAP is a key player in the development of autoimmune disease.

Keywords: SLAM-associated protein (SAP); IgA nephropathy; SAP knockout mice; X-linked lymphoproliferative syndrome; rheumatoid arthritis; autoimmune disease; apoptosis

Document Type: Research article

DOI: http://dx.doi.org/10.1196/annals.1398.003

Affiliations: 1: Department of Rheumatology and Hematology, Nihon University Nerima Hikarigaoka Hospital, Tokyo, Japan 2: Department of Rheumatology and Hematology, Nihon University, Itabashi Hospital, Tokyo, Japan 3: Kyowa Hakko Kogyo Co., Science and Technology Department, Tokyo, Japan

Publication date: 2007-08-01