IngentaConnect Regulatory T Cells and Systemic Lupus Erythematosus

Authors: PARIETTI, VÉRONIQUE¹; CHIFFLOT, HÉLÈNE¹; MULLER, SYLVIANE¹; MONNEAUX, FANNY¹

Source: Annals of the New York Academy of Sciences, Volume 1108, Number 1, June 2007 , pp. 64-75(12)

Abstract:

Regulatory T cells, especially CD4⁺CD25⁺ T cells, “natural killer” T cells and γδ T cells, are central in the maintenance of peripheral tolerance and the protection from the development of autoimmune diseases. Numerical or functional modifications of these cell populations were demonstrated to lead to the breakdown of tolerance and the emergence of autoimmunity. Involvement of regulatory T cells in the pathogenesis of systemic autoimmune diseases, such as systemic lupus erythematosus, might be of first importance. In murine models and patients with lupus, these regulatory T cells seem to be reduced in number. Functional deficiencies have also been described in a few studies. A better knowledge of regulatory T cell functional properties in systemic autoimmune diseases is essential to manipulate these cells and hopefully to restore immune tolerance.

Keywords: regulatory T cells; CD4+CD25+ T cells; NKT cells; γδ; T cells; tolerance; autoimmunity; systemic lupus erythematosus

Document Type: Research article

DOI: 10.1196/annals.1422.007

Affiliations: 1: CNRS UPR9021 (Immunologie et Chimie Thérapeutiques), 67084 Strasbourg, France

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