Autoimmunity and β Cell Regeneration in Mouse and Human Type 1 Diabetes

Authors: ABLAMUNITS, VITALY¹; SHERRY, NICOLE A.²; KUSHNER, JAKE A.³; HEROLD, KEVAN C.¹

Source: Annals of the New York Academy of Sciences, Volume 1103, Number 1, April 2007 , pp. 19-32(14)

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Abstract:

Accumulating data from animal models of type 1 diabetes and some findings from clinical studies suggest that autoimmune destruction of islet β cells is associated with enhanced β cell regeneration. Successful immune therapies, aimed at preservation of islet cell mass, result in a remarkable reduction of β cell regeneration. Treated or not, as long as the task of treatment is limited by “making peace” with autoimmunity, the process of β cell loss continues. Additional therapeutic modalities capable of stimulating β cell regeneration in the absence of active autoimmune destruction are urgently needed.

Keywords: immune therapy; type 1 diabetes; β cell regeneration

Document Type: Research article

DOI: http://dx.doi.org/10.1196/annals.1394.006

Affiliations: 1: Section of Immunobiology and Department of Medicine, Yale University, New Haven, Connecticut, USA 2: Department of Pediatrics, Massachusetts General Hospital, Boston, Massachusetts, USA 3: Division of Endocrinology, Children's Hospital of Philadelphia, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania, USA

Publication date: 2007-04-01