Authors: romeiro, f. g.¹; corá, l. a.²; de andreis, u.²; américo, m. f.³; oliveira, r. b.³; baffa, o.⁴; miranda, j. r. a.²

Source: Neurogastroenterology and Motility, Volume 18, Number 12, December 2006 , pp. 1078-1083(6)

Publisher: Wiley-Blackwell

Abstract:

 

Motility patterns play a major role in human colonic functions; however, its physiological significance is poorly understood. Several studies have been introducing the Alternating Current Biosusceptometry (ACB) as a valuable tool in gastroenterology and pharmaceutical research. Using gold standard techniques, great effort has been made to validate ACB as a method for measuring gastrointestinal motility in humans and animals. The aim of this study was to evaluate caecocolonic motility and its response to a meal in healthy volunteers. The results showed a dominant frequency of 3.17 ± 0.13 cycles per minute (mean ± SD) that remained unchanged even after a standardized meal (P > 0.01). The colonic response to a meal was recorded as a considerable increase in amplitude, reflected by motility index (P < 0.01) and was observed for all the volunteers. The caecocolonic motility could be assessed by the ACB providing new insights into physiological patterns of motility. Moreover, the method is non-invasive, radiation-free, cost-effective and independent of bowel preparation.

Keywords: Alternating Current Biosusceptometry; biomagnetism; colonic motility; feeding response

Document Type: Technical note

DOI: http://dx.doi.org/10.1111/j.1365-2982.2006.00838.x

Affiliations: 1: Departamento de Clínica Médica, FMB, Universidade Estadual Paulista - UNESP, Botucatu, São Paulo, Brazil 2: Departamento de Física e Biofísica, IBB, Universidade Estadual Paulista - UNESP, Botucatu, São Paulo, Brazil 3: Departamento de Clínica Médica, FMRP, Universidade de São Paulo - USP, Ribeirão Preto, São Paulo, Brazil 4: Departamento de Física e Matemática, FFCLRP, Universidade de São Paulo - USP, Ribeirão Preto, São Paulo, Brazil

Publication date: 2006-12-01

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