Invasive aspergillosis with polyarthritis

Authors: Mekan, S. F.1; Saeed, O.1; Khan, J. A.2

Source: Mycoses, Volume 47, Numbers 11-12, December 2004 , pp. 518-520(3)

Publisher: Wiley-Blackwell

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Abstract:

Summary

We report a case of septic arthritis of multiple joints in an 18-year-old male caused by Aspergillus fumigatus. His initial presentation was of low-grade fever followed by involvement of both knee and ankle joints. Later, there was also involvement of metacarpophalangeal joints. Diagnosis was based on biopsy and culture of the skin and joint lesions. The symptoms resolved readily under administration of itraconazole. We recommend that clinicians should be alerted of potential fungal etiology in cases of fever and chronic arthritis, which is unresponsive to conventional medical therapy.

German
Zusammenfassung

Es wird über einen Fall von Aspergillus fumigatus-bedingter septischer Arthritis mehrerer Gelenke bei einem 18-jährigen Mann berichtet. Die Anfangssymptomatik präsentierte sich als mäßiges Fieber gefolgt von Beschwerden in beiden Knie- und Fußgelenken. Später traten Beschwerden an den Mittelhandgelenken auf. Die Diagnose stützte sich auf Biopsie- und Kulturbefunde aus Haut- und Gelenkläsionen. Die Beschwerden heilten unter Itraconazol-Therapie rasch ab. Bei fieberhafter chronicher Arthritis sollte deshalb stets eine Pilziätiologie erwogen werden, wenn das Krankheitsbild nicht auf eine konventionelle Therapie anspricht.

Keywords: Aspergillosis; Aspergillus fumigatus; invasive infection; polyarthritis; Aspergillosis; Aspergillus fumigatus; invasive Infektion; polyarthritis

Document Type: Research article

DOI: http://dx.doi.org/10.1111/j.1439-0507.2004.01031.x

Affiliations: 1: Biological and Biomedical Sciences 2: Medicine, The Aga Khan University Hospital, Karachi, Pakistan

Publication date: 2004-12-01

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