In vitro susceptibility of Cryptococcus neoformans serotypes to GM 237354 derivative of the sordarin class

Authors: Torres-Rodríguez, J. M.; Morera, Y.; Baró, T.; López, O.; Alía, C.; Jiménez, T.

Source: Mycoses, Volume 45, Number 8, October 2002 , pp. 313-316(4)

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Abstract:

Summary.

In vitro susceptibility to the sordarin derivative GM 237354 and amphotericin B were tested in a total of 190 Cryptococcus neoformans clinical isolates from different geographical areas of Spain and South American countries. Minimal inhibitory concentrations (MICs) were obtained using the NCCLS reference microbroth dilution method and analysed according the serotypes of Cr. neoformans. The MICs for amphotericin B were lower than 1.0 μg ml⁻¹ (MIC_90% 0.5 μg ml⁻¹, MIC_50% 0.125 μg ml⁻¹) but five isolates showed MICs of 2.0 μg ml⁻¹ to GM 237354 (MIC_90% 1.0 μg ml⁻¹, MIC_50% 0.5 μg ml⁻¹). Cryptococcus neoformans var. gattii serotype B, was significantly less susceptible than A and AD serotypes (P=0.047 and P=0.022, respectively).

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Zusammenfassung.

An 190 klinischen Isolaten von Cryptococcus neoformans aus unterschiedlichen Regionen Spaniens und Südamerikas wurde die Empfindlichkeit in vitro für das Sordanin-Derivat GM 237354 im Vergleich zu Amphotericin B getestet. Die MHK-Werte wurden mittels NCCLS-Mikroverdünnungs-Referenzmethode erhoben und ein Vergleich nach Cr. neoformans-Serotypen durchgeführt. Die MHKs für Amphotericin B lagen unter 1.0 µg ml⁻¹ (MHK_90% 0.5 μg ml⁻¹, MHK_50% 0.125 μg ml), aber fünf Isolate zeigten MHKs von 2.0 μg ml⁻¹ für GM 237354 (MHK_90% 1.0 μg ml⁻¹, MHK_50% 0.5 μg ml⁻¹). Cryptococcus neoformans var. gatti Serotyp. B war signifikant weniger empfindlich als die Serotypen A und AD (P=0.047 bzw. P=0.022).

Keywords: Cryptococcus neoformans; serotypes; antifungal susceptibility; sordarin; amphotericin B; Cryptococcus neoformans; Serotypen; Antimycestische; Empfindlichkeit; Sordarin; Amphotericin

Document Type: Research article

DOI: http://dx.doi.org/10.1046/j.1439-0507.2002.00787.x

Affiliations: 1: Clinical and Experimental Mycology Group (GREMEC), Institut Municipal d'Investigació Mèdica (IMIM), Autonomous University of Barcelona, Barcelona, Spain.

Publication date: 2002-10-01

In vitro susceptibility of Cryptococcus neoformans serotypes to GM 237354 derivative of the sordarin class

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