A population genomic approach to map recent positive selection in model species

Authors: PAVLIDIS, P.; HUTTER, S.; STEPHAN, W.

Source: Molecular Ecology, Volume 17, Number 16, August 2008 , pp. 3585-3598(14)

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Abstract:

Based on nearly complete genome sequences from a variety of organisms data on naturally occurring genetic variation on the scale of hundreds of loci to entire genomes have been collected in recent years. In parallel, new statistical tests have been developed to infer evidence of recent positive selection from these data and to localize the target regions of selection in the genome. These methods have now been successfully applied to Drosophila melanogaster, humans, mice and a few plant species. In genomic regions of normal recombination rates, the targets of positive selection have been mapped down to the level of individual genes.

Keywords: adaptation; genome scan; genome variation; model species; selective sweep; statistical tests

Document Type: Research article

DOI: http://dx.doi.org/10.1111/j.1365-294X.2008.03852.x

Publication date: 2008-08-01