IngentaConnect The disposition of theophylline in camels after intravenous admin...

Authors: Wasfi¹; Elghazali¹; Boni¹; Hadi¹; Alhadrami²; Almuhrami¹; Alkatheeri¹; Barezaiq¹; Agha¹; Wajid³

Source: Journal of Veterinary Pharmacology & Therapeutics, Volume 22, Number 4, August 1999 , pp. 255-260(6)

Abstract:

The pharmacokinetics of theophylline were determined after an intravenous (i.v.) dose of 2.36 mg/kg in six camels and 4.72 mg/kg body weight in three camels. The data obtained (median and range) for the low and high dose, respectively, were as follows: the distribution half-lives (t_1/2α) were 1.37 (0.64-3.25) and 2.66 (0.83-3.5) h, the elimination half-lives (t_1/2β) were 11.8 (8.25-14.9) and 10.4 (10.0-13.5) h, the steady state volumes of distribution (V_ss) were 0.88 (0.62-1.54) and 0.76 (0.63-0.76) L/kg, volumes of the central compartment (V_c) were 0.41 (0.35-0.63) and 0.51 (0.36-0.52) L/kg, total body clearances (Cl_t) were 62.3 (39.4-97.0) and 50.2 (47.7-67.4) mL/h.kg body weight and renal clearance (V_r) for the low dose was 0.6 (0.42-0.96) mL/h.kg body weight. There was no significant difference in the pharmacokinetic parameters between the two doses. Theophylline protein binding at a concentration of 5 μg/mL was 32.2 ± 3.3%. Caffeine was identified as a theophylline metabolite but its concentration in serum and urine was small. Based on the pharmacokinetic values obtained in this study, a dosage of 7.5 mg/kg body weight administered by i.v. injection at 12 h intervals can be recommended. This dosing regimen should achieve an average steady state serum concentration of 10 μg/mL with peak serum concentration not exceeding 15 μg/mL.

Document Type: Research article

DOI: 10.1046/j.1365-2885.1999.00220.x

Affiliations: 1: Camelracing Laboratory, Forensic Science Laboratory, P.O. Box 253, Abu Dhabi, United Arab Emirates., 2: Animal Production, Faculty of Agriculural Sciences, United Arab Emirates University, P.O. Box: 17555, Al-Ain, United Arab Emirates., 3: Camelracing Laboratory, Forensic Science Laboratory, P.O. Box 253, Abu Dhabi, United Arab Emirates.

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The disposition of theophylline in camels after intravenous administration