Authors: Su, F.-H.¹; Chen, J.-D.²; Cheng, S.-H.³; Sung, K.-Y.⁴; Jeng, J.-J.⁵; Chu, F.-Y.⁶

Source: Journal of Viral Hepatitis, Volume 15, Number 1, January 2008 , pp. 14-19(6)

Publisher: Wiley-Blackwell

Abstract:

Summary. 

Hepatitis B virus (HBV) infection and its sequelae remain a major health problem for Taiwan. The national hepatitis B (HB) vaccination programme was first launched in 1984 to combat the spread of this infection. This study examined the status of HBV infection amongst students at a Taiwanese university in 2005, 18 years after the implementation of a nation-wide mass HB vaccination programme. In 2005, 5875 new university entrants, who were born during the period 1 July 1976 to 30 June 1988, were subdivided into one of 12 one-year-interval birth-year cohorts. Each student was individually tested for serum hepatitis B surface antigen (HBsAg), Antibody to hepatitis B surface antigen (anti-HBs) and antibody to hepatitis B core antigen (anti-HBc) status. We observed a declining trend of past exposure to HB infection from 48.7% (1976 birth-year cohort) to 5.2% (1987 birth-year cohort). The prevalence of chronic HB infection also declined from 14.5% (1976 birth-year cohort) to 1.9% (1987 birth-year cohort). The prevalence of persistent HB immunity through (earlier) active vaccination declined from 72% (1984 birth-year cohort) to 41.6% (1987 birth-year cohort). The prevalence of HB infection-naïve individuals increased from 18.2% (1984 birth-year cohort) to 53.1% (1987 birth-year cohort). This study demonstrates that as the implementation of the mass HB vaccination programme in 1984, the incidence of HB infection in Taiwan has declined, although a `waning-off' effect of serum anti-HBs to low or undetectable levels, which may not provide protection, amongst this student population has arisen, 18 years following the implementation of the nation-wide HB vaccination programme. Such a situation may mean that these individuals may not be effectively protected against future HB infection. A booster dose of HB vaccine, given 18 years following HB vaccination, perhaps even earlier, should be considered.

Keywords: hepatitis B virus; mass-vaccination programme; Taiwan

Document Type: Research article

DOI: http://dx.doi.org/10.1111/j.1365-2893.2007.00890.x

Affiliations: 1: Department of Family Medicine, Far Eastern Memorial Hospital, Pan Chiao, Taipei Hsien, Taiwan 2: Department of Family Medicine, Shin Kong Wu Ho-Su Memorial Hospital, Taipei, Taiwan 3: Yangmei Township Public Health Center, Tao Yuan Hsien, Taiwan 4: School of Medicine 5: Student Health Service, Fu Jen Catholic University, Hsin-Chuang, Taipei Hsien, Taiwan 6: Department of Clinical Pathology, Far Eastern Memorial Hospital, Pan Chiao, Taipei Hsien, Taiwan

Publication date: 2008-01-01

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