Authors: Kurbanov, F.¹; Tanaka, Y.¹; Elkady, A.¹; Oyunsuren, T.²; Mizokami, M.¹

Source: Journal of Viral Hepatitis, Volume 14, Number 9, September 2007 , pp. 667-674(8)

Publisher: Wiley-Blackwell

Abstract:

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An estimated incidence of hepatocellular carcinoma (HCC) in Mongolia is currently one of the highest in the world. According to previous reports, the sero-prevalence of hepatitis B (HBV) and hepatitis C (HCV) viruses in general population of the country is very high (HBV, 10% and HCV, 15%, respectively). Moreover, the majority (75-100%) of the HBV-infected individuals have co-infection with hepatitis Delta virus (HDV). Despite reported observations that HBV + HDV/HCV co-infection have significantly stronger association with HCC when compared with HCV-monoinfection, the later is still frequently observed among Mongolian HCC patients (39%). In this study, an approach based on principles of population genetics and mathematical epidemiology was used to trace an epidemic history of HCV and HDV. In agreement with the sero-epidemiological and social-historical background of the country, the results have demonstrated that the viruses had different epidemic dynamics in Mongolia; HCV was characterized by earlier epidemic expansion, whereas HDV spread with approximately 50 years lag. This may explain the comparable contribution of the HCV-monoinfection and HBV + HDV co-infection in current HCC rate despite different levels of risk of carcinogenesis. Used approach is useful in evaluation of current and prospective disease burden.

Keywords: coalescence theory; hepatitis C virus; hepatitis Delta virus; hepatocellular carcinoma; molecular epidemiology; Mongolia

Document Type: Research article

DOI: http://dx.doi.org/10.1111/j.1365-2893.2007.00864.x

Affiliations: 1: Department of Clinical Molecular Informative Medicine, Nagoya City University Graduate School of Medical Sciences, Nagoya, Japan 2: Laboratory of Molecular Biology, The Institute of Biology, Mongolian Academy of Sciences, Ulaanbaatar, Mongolia

Publication date: 2007-09-01

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