Skip to main content

Free Content The effect of fibrinogen concentrate on thrombocytopenia

Download Article:

You have access to the full text article on a website external to Ingenta Connect.

Please click here to view this article on Wiley Online Library.

You may be required to register and activate access on Wiley Online Library before you can obtain the full text. If you have any queries please visit Wiley Online Library

Summary. 

Objectives: The hypothesis that the administration of fibrinogen concentrate enables restoration of impaired clot formation and increased bleeding in severe thrombocytopenia was tested. Methods: Thirty pigs were anesthetized, instrumented for blood sampling (routine coagulation tests, modified thrombelastography ROTEM®), hemodynamic monitoring and platelet apheresis to a target below 30 × 109 L−1 after splenectomy. Thereafter 10 each of the animals randomly received two apheresis platelet concentrates, 250 mg kg−1 fibrinogen concentrate or normal saline solution. A standardized liver injury was subsequently inflicted to induce uncontrolled hemorrhage. Results: Median (Q1, Q3) clot firmness increased significantly more in thrombocytopenic pigs after fibrinogen administration (42 mm (41, 43) to 60 mm (57, 63)) than following platelet transfusion (40 mm (37, 45) to 52 mm (48, 55), P = 0.0004) or placebo (45 mm (41, 48) to 45 mm (43, 46), P = 0.0002). Median blood loss velocity after liver injury was significantly less with fibrinogen (33 mL min−1, P = 0.005) than with platelets (62 mL min−1, P = 0.037) or saline (84 mL min−1, P = 0.005), and median survival time after liver injury was 55 min in the fibrinogen, 26 min in the platelet (P = 0.035) and 19 min in the saline group (P = < 0.0001). Conclusions: These data show for the first time that impaired clot formation during thrombocytopenia improves with administration of fibrinogen concentrate, which results in a slowdown of blood loss and prolonged survival.
No References
No Citations
No Supplementary Data
No Data/Media
No Metrics

Keywords: apheresis; bleeding disorder; fibrinogen; platelet concentrate; thrombocytopenia

Document Type: Research Article

Affiliations: 1: Department of Anaesthesiology and Intensive Care Medicine 2: Department of Pediatrics 3: Central Institute for Blood Transfusion 4: Department of General, Thoracic and Transplantation Surgery, Laboratory for Experimental Surgery 5: Division of Histology and Embryology 6: Department of General and Surgical Critical Care Medicine, Innsbruck Medical University, Innsbruck, Austria 7: National Haemophilia Centre, Ministry of Health, Sheba Medical Centre, Tel Aviv, Hashomer, Israel

Publication date: 2007-05-01

  • Access Key
  • Free content
  • Partial Free content
  • New content
  • Open access content
  • Partial Open access content
  • Subscribed content
  • Partial Subscribed content
  • Free trial content
Cookie Policy
X
Cookie Policy
Ingenta Connect website makes use of cookies so as to keep track of data that you have filled in. I am Happy with this Find out more