Skip to main content

Free Content Time–course of cerebrospinal fluid histamine in the wake‐consolidated squirrel monkey

Download Article:

You have access to the full text article on a website external to Ingenta Connect.

Please click here to view this article on Wiley Online Library.

You may be required to register and activate access on Wiley Online Library before you can obtain the full text. If you have any queries please visit Wiley Online Library


Central nervous system (CNS) histamine is low in individuals with narcolepsy, a disease characterized by severe fragmentation of both sleep and wake. We have developed a primate model, the squirrel monkey, with which we can examine the role of the CNS in the wake‐consolidation process, as these primates are day‐active, have consolidated wake and sleep and have cerebrospinal fluid (CSF) that is readily accessible. Using this model and three distinct protocols, we report herein on the role of CNS histamine in the wake consolidation process. CSF histamine has a robust daily rhythm, with a mean of 24.9 ± 3.29 pg mL−1, amplitude of 31.7 ± 6.46 pg mL−1 and a peak at 17:49 ± 70.3 min (lights on 07:00–19:00 hours). These levels are not significantly affected by increases (up to 161 ± 40.4% of baseline) or decreases (up to 17.2 ± 2.50% of baseline) in locomotion. In direct contrast to the effects of sleep deprivation in non‐wake‐consolidating mammals, in whom CSF histamine increases, pharmacologically induced sleep (γ‐hydroxybutyrate) and wake (modafinil) have no direct effects on CSF histamine concentrations. These data indicate that the time–course of histamine in CSF in the wake‐consolidated squirrel monkey is robust against variation in activity and sleep and wake‐promoting pharmacological compounds, and may indicate that histamine physiology plays a role in wake‐consolidation such as is present in the squirrel monkey and humans.
No References
No Citations
No Supplementary Data
No Article Media
No Metrics

Document Type: Research Article

Affiliations: 1: Department of Psychology, Tokyo Metropolitan Institute for Neuroscience, Tokyo, Japan 2: Department of Psychiatry and Behavioral Sciences, Stanford University, Stanford, CA, USA

Publication date: 01 April 2012

  • Access Key
  • Free content
  • Partial Free content
  • New content
  • Open access content
  • Partial Open access content
  • Subscribed content
  • Partial Subscribed content
  • Free trial content
Cookie Policy
Cookie Policy
Ingenta Connect website makes use of cookies so as to keep track of data that you have filled in. I am Happy with this Find out more