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Free Content Fragmentation of the rest-activity rhythm correlates with age-related cognitive deficits

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Abstract:

Summary

Aging affects both cognitive performance and the sleep-wake rhythm. The recent surge of studies that support a role of sleep for cognitive performance in healthy young adults suggests that disturbed sleep-wake rhythms may contribute to ‘age-related’ cognitive decline. This relationship has however not previously been extensively investigated. The present correlational study integrated a battery of standardized cognitive tests to investigate the association of mental speed, memory, and executive function with actigraphically recorded sleep-wake rhythms in 144 home-dwelling elderly participants aged 69.5 ± 8.5 (mean ± SD). Multiple regression analyses showed that the partial correlations of the fragmentation of the sleep-wake rhythm with each of the three cognitive domains (r = −0.16, −0.19, and −0.16 respectively) were significant. These associations were independent from main effects of age, implying that a unique relationship between the rest-activity rhythm and cognitive performance is present in elderly people.

Keywords: actigraphy; aging; circadian rhythm; cognitive function; sleep

Document Type: Research Article

DOI: https://doi.org/10.1111/j.1365-2869.2008.00704.x

Affiliations: 1: Department of Neurology, Medical Center Alkmaar, Alkmaar, The Netherlands 2: Department of Neurology, Medical Center Leeuwarden, Leeuwarden, The Netherlands 3: Department of Clinical Neuropsychology, Vrije Universiteit, Amsterdam, The Netherlands

Publication date: 2009-03-01

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