Skip to main content

Free Content Mortality risk factors in sleep apnoea: a matched case–control study

Download Article:

You have access to the full text article on a website external to Ingenta Connect.

Please click here to view this article on Wiley Online Library.

You may be required to register and activate access on Wiley Online Library before you can obtain the full text. If you have any queries please visit Wiley Online Library

Abstract:

Summary

Sleep apnoea syndrome was reported to be associated with increased mortality but it is not known if this association is independent of obesity and co-morbidities. The present study investigated predictors of mortality in a large cohort of men with sleep apnoea using a case–control design. The study population consisted of 10 981 men diagnosed during 1991–2000 by whole-night polysomnography with sleep apnoea; 331 men died prior to 1 September 2001, of whom 277 were matched by age, gender, site and time of study to patients who were alive in September 2001. Multivariate analysis revealed that all-cause mortality was associated with chronic obstructive pulmonary disease (COPD) (odds ratio, OR: 7.07, 95% CI 2.75–18.16), chronic heart failure (CHF) (OR: 5.47, 95% CI 1.06–28.31), diabetes mellitus (DM) (OR: 3.30, 95% CI 1.51–7.20) and body mass index (BMI) (increase of 5 kg m−2, OR: 1.44, 95% CI: 1.04–1.99). Chronic upper airway problems were associated with survival (OR: 0.45, 95% CI 0.23–0.90). There were significant interactions between respiratory disturbance index and BMI and COPD. Mortality of patients younger than the median age (62 years) was associated with COPD, DM and an interaction between BMI and apnoea severity. Predictors of mortality for the older patients were COPD, CHF and DM. We conclude that all-cause mortality in sleep apnoea is associated with co-morbidities and obesity. Severity of sleep apnoea affects mortality by interacting with obesity and lung disease.

Keywords: all-cause mortality; body mass index; case–control; sleep apnoea

Document Type: Research Article

DOI: http://dx.doi.org/10.1111/j.1365-2869.2007.00578.x

Publication date: March 1, 2007

bsc/jsr/2007/00000016/00000001/art00016
dcterms_title,dcterms_description,pub_keyword
6
5
20
40
5

Access Key

Free Content
Free content
New Content
New content
Open Access Content
Open access content
Subscribed Content
Subscribed content
Free Trial Content
Free trial content
Cookie Policy
X
Cookie Policy
Ingenta Connect website makes use of cookies so as to keep track of data that you have filled in. I am Happy with this Find out more