Skip to main content

Free Content Habitual snoring is associated with elevated hemoglobin A1c levels in non-obese middle-aged adults

Download Article:

You have access to the full text article on a website external to ingentaconnect.

Please click here to view this article on Wiley Online Library.

You may be required to register and activate access on Wiley Online Library before you can obtain the full text. If you have any queries please visit Wiley Online Library



Hemoglobin A1c (HbA1c) is an indicator of long-term glycemic control. The purpose of this study was to determine whether habitual snoring is associated with increased HbA1c levels in non-obese and normoglycemic middle-aged men and women. A total of 6981 subjects (3362 men and 3619 women) aged 40–69 years from the Korean Health and Genome Study were examined for the study. Each participant received a comprehensive physical examination as well as a set of questions pertaining to demographic characteristics and snoring frequency. Habitual snoring was defined as a snoring frequency of ≥4 days week−1. After adjusting for age, abdominal obesity, and other confounding covariates, male habitual snorers showed a 1.69-fold excess [95% confidence interval (CI) 1.30–2.19] odds of having a high HbA1c level. Similarly, premenopausal women with habitual snoring had a 2.31 times (95% CI 1.22–4.39) significantly higher odds of having elevated HbA1clevels compared with non-snorers. This association was not found in postmenopausal women. Multivariate analysis revealed that male habitual snorers aged 40–50 had a 2.08-fold excess (95% CI 1.40–3.09) risk of having an elevated HbA1c level. In male habitual snores over 50, the strength of association was attenuated. Our findings based on cross-sectional data support a hypothesis that habitual snoring is associated with impaired glucose tolerance even in non-obese and normoglycemic men and premenopausal women. However, as waist circumference as an index of abdominal obesity (visceral adiposity) in the present study may only partially represent the effect of visceral fat, there may be a residual confounding from visceral obesity in our result. Longitudinal follow-up studies are necessary to confirm the association between sleep-disordered breathing and impaired glucose tolerance and to examine the causal relationship in a healthy population without obesity and diabetes.

Keywords: hemoglobin A1c; impaired glucose tolerance; menopause; sleep disorders

Document Type: Research Article


Affiliations: 1: Institute of Human Genomic Study, Korea University Medical Science Research Center, Seoul, Korea 2: Pulmonary Sleep Disorder Center, Korea University Ansan Hospital, Gyeonggi-do, Korea 3: Center for Genome Science, Korea National Institute of Health, Seoul, Korea 4: Division of Pulmonary and Critical Care Medicine, Department of Internal Medicine, Korea University Ansan Hospital, Gyeonggi-do, Korea

Publication date: December 1, 2006


Access Key

Free Content
Free content
New Content
New content
Open Access Content
Open access content
Subscribed Content
Subscribed content
Free Trial Content
Free trial content
Cookie Policy
Cookie Policy
ingentaconnect website makes use of cookies so as to keep track of data that you have filled in. I am Happy with this Find out more
Real Time Web Analytics