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Free Content CSF hypocretin measures in patients with obstructive sleep apnea

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The majority of patients with narcolepsy-cataplexy were reported to have very low cerebrospinal fluid (CSF) hypocretin-1 (orexin-A) levels. The hypocretin-1 levels of secondary excessive daytime sleepiness (EDS) disorders are not known. In this study, we found that CSF hypocretin levels in the patients with obstructive sleep apnea syndrome were within the control range. The low hypocretin levels seem to reflect only the presence of cataplexy and DR2 positive in narcoleptics but not EDS itself.

Keywords: cerebrospinal fluid; hypocretin; narcolepsy; obstructive sleep apnea; orexin

Document Type: Research Article


Affiliations: 1: Department of Neuropsychiatry, Akita University School of Medicine, Akita 2: Department of Neuropsychiatry, Juntendo University School of Medicine, Tokyo 3: Department of Neurology, Kansai-Denryoku Hospital, Osaka 4: Department of Neuropsychiatry, Asahikawa Medical College, Asahikawa, Japan

Publication date: December 1, 2003


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