Skip to main content

Free Content CSF hypocretin-1 (orexin-A) concentrations in narcolepsy with and without cataplexy and idiopathic hypersomnia

Download Article:

You have access to the full text article on a website external to Ingenta Connect.

Please click here to view this article on Wiley Online Library.

You may be required to register and activate access on Wiley Online Library before you can obtain the full text. If you have any queries please visit Wiley Online Library

We measured cerebrospinal fluid (CSF) hypocretin-1 levels in 11 patients with narcolepsy–cataplexy, five with narcolepsy without cataplexy and 12 with idiopathic hypersomnia (IHS). All patients were Japanese. As reported in Caucasian patients, undetectable or very low hypocretin-1 levels were observed in most (9 out of 11) Japanese narcolepsy–cataplexy patients. Our hypocretin-deficient narcoleptics included three prepubertal cases within few months after the disease onset. All nine hypocretin-deficient patients were human leuckocyte antigen (HLA) DR2 positive, while two who had normal CSF hypocretin-1 levels were HLA DR2 negative. In contrast, none of the narcolepsy without cataplexy and IHS subjects had undetectable low levels. Low CSF hypocretin-1 is therefore very specific for HLA DR2 positive narcolepsy–cataplexy, and the deficiency is likely to be established at the early stage of the disease.
No References
No Citations
No Supplementary Data
No Article Media
No Metrics

Keywords: REM sleep propensity; rapid eye movement sleep; short-term REM sleep homeostasis; sleep cycle; sleep deprivation; ultradian rhythms

Document Type: Original Article

Affiliations: 1: Department of Neuropsychiatry, Akita University School of Medicine, Akita, Japan, 2: Department of Neuropsychiatry, Juntendo University School of Medicine, Tokyo, Japan, 3: Department of Neuropsychiatry, Asahikawa Medical College, Asahikawa, Japan, 4: Department of Pediatrics, Nagoya City University Medical School, Nagoya, Japan, 5: Department of Pediatric Neurology, National Center Hospital for Mental, Nervous and Muscular Disorders, National Center of Neurology and Psychiatry, Tokyo, Japan, 6: Center for Narcolepsy, Stanford University School of Medicine, CA, USA

Publication date: 2002-03-01

  • Access Key
  • Free content
  • Partial Free content
  • New content
  • Open access content
  • Partial Open access content
  • Subscribed content
  • Partial Subscribed content
  • Free trial content
Cookie Policy
Cookie Policy
Ingenta Connect website makes use of cookies so as to keep track of data that you have filled in. I am Happy with this Find out more