Skip to main content

Free Content Human insulin gene insertion in mice. Effects on the sleep–wake cycle?

Download Article:

You have access to the full text article on a website external to Ingenta Connect.

Please click here to view this article on Wiley Online Library.

You may be required to register and activate access on Wiley Online Library before you can obtain the full text. If you have any queries please visit Wiley Online Library

Recently, insulin synthesis and the presence of an insulin receptor have been demonstrated in the brain. Intracerebroventricular infusion of insulin causes a selective increase in the amount of slow-wave sleep. In the present study, the sleep–wake cycle of transgenic mice, with or without habenular neuronal expression of the human insulin gene, was studied to investigate the possible role of brain insulin as a sleep modulator. Slow-wave sleep duration was increased in those mice expressing human insulin in the habenula. However, it is possible that this effect was not due to expression of the insulin transgene, but to the genetic background of one of the parental strains (CBA) used for insertion of the transgene. Users of transgenic mice should be aware of this possibility and be cautious in interpreting results when hybrid embryos are used as transgene recipients.
No References
No Citations
No Supplementary Data
No Data/Media
No Metrics

Keywords: human insulin; paradoxical sleep; slow-wave sleep; transgenic mice

Document Type: Research Article

Affiliations: 1: INSERM U480, Université Claude Bernard, Lyon, France 2: Institut des Neurosciences CNRS URA 1488, Université Pierre et Marie Curie, Paris, France 3: INSERM U257, Institut Cochin de Génétique Moléculaire, Paris, France

Publication date: 1999-03-01

  • Access Key
  • Free content
  • Partial Free content
  • New content
  • Open access content
  • Partial Open access content
  • Subscribed content
  • Partial Subscribed content
  • Free trial content
Cookie Policy
X
Cookie Policy
Ingenta Connect website makes use of cookies so as to keep track of data that you have filled in. I am Happy with this Find out more