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Free Content Obstructive sleep apnoea syndrome in hereditarygelsolin-related amyloidosis

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Abstract:

Summary

Gelsolin-related amyloidosis (AGel amyloidosis) is a rare autosomal dominant disorder, reported worldwide in kindreds carrying a G654A or G654T gelsolin gene mutation. The main clinical signs are cutis laxa, cranial and peripheral neuropathy, and corneal lattice dystrophy but heavy intermittent snoring also occurs. To evaluate whether sleep apnoea is present we performed nocturnal sleep recordings, cephalometric and spirometric analyses and multiple sleep latency tests (MSLT) in five snoring patients with a G654A gelsolin gene mutation. Four patients had obstructive sleep apnoea syndrome (OSAS) with redundant oropharyngeal and hypopharyngeal soft tissues, macroglossia and cranial neuromuscular dysfunction. The fifth patient had hypersomnia without obstructive sleep apnoea. Nasal continuous positive airway pressure (CPAP) was an effective treatment. This study presents the first evidence in favour of an association between AGel amyloidosis and OSAS, but further studies are needed to define the prevalence of OSAS and the pathogenetic roles of amyloid and variant gelsolin in its evolution.

Keywords: Finnish type (FAF); cranial neuropathy; familial amyloidosis; gelsolin; hereditary gelsolin-related amyloidosis; macroglossia; obstructive sleep apnoea syndrome

Document Type: Research Article

DOI: http://dx.doi.org/10.1046/j.1365-2869.1999.00140.x

Affiliations: 1: Department of Clinical Neurosciences, Helsinki University Central Hospital, Helsinki, Finland 2: Department of Pedodontics and Orthodontics, University of Helsinki, Helsinki, Finland

Publication date: June 1, 1999

bsc/jsr/1999/00000008/00000002/art00007
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