Skip to main content

Free Content Segregation of HLA genes in multicase narcolepsy families

Download Article:

The full text article is temporarily unavailable.

We apologise for the inconvenience. Please try again later.

In the past 15 years, 411 sporadic narcolepsy patients have been diagnosed in the Hephata Klinik, Schwalmstadt, Germany. They were explored for presence or absence of excessive daytime sleepiness and narcolepsy in their relatives. A subset of 39 patients were explored for presence or absence of parasomnias. Six patients had more than one relative affected by narcolepsy-cataplexy. Forty-seven family members were investigated with the Stanford Center for Narcolepsy Sleep Inventory and a standardized parasomnia questionnaire. Twenty-four relatives had nocturnal polysomnographies and Multiple Sleep Latency Tests. HLA class I typing was performed in all sporadic and familial cases, class II and microsatellite typing was performed in all members of multicase families. Based on the Finnish prevalence study by Hublin et al., 1994, the relative risk for first degree relatives to develop narcolepsy-cataplexy was in our sample 16.5, 34.2 for excessive daytime sleepiness and 426.9 for parasomnias. Cataplexy, excessive daytime sleepiness and single narcoleptic symptoms in the multicase families segregate with the DRB1*1501, CARII:200, CARI:103, DQB1*0602 haplotype. In two families, members with narcolepsy and isolated symptoms have inherited the DRB1*1501/DQB1*0602 haplotype from the non-affected parent. The observed segregations in these two families may support the view that narcoleptic symptoms are expressed by DRB1*1501/DQB1*0602 carriers, independent of haplotype origin. Parasomnias do not segregate with a specific haplotype. The frequency of parasomnias in narcolepsy is much higher than in the general population. The empirical risk for first degree family members of narcolepsy patients to develop cataplexy seems to be low, whereas it is higher for EDS and highest for parasomnias.
No References
No Citations
No Supplementary Data
No Article Media
No Metrics

Keywords: HLA typing; multicase families; narcolepsy; paraso

Document Type: Research Article

Affiliations: 1: Institute for Clinical Immunology and Transfusion Medicine, University of Giessen, Germany 2: Department of Clinical Neurophysiology, Karolinska Hospital, Stockholm, Sweden 3: Hephata Klinik, Schimmelpfengstr. 2, D-34613 Schwalmstadt-Treysa, Germany. Tel: +49 (0)6691-182002; Fax: +49 (0)6691-2823.

Publication date: 1998-06-01

  • Access Key
  • Free content
  • Partial Free content
  • New content
  • Open access content
  • Partial Open access content
  • Subscribed content
  • Partial Subscribed content
  • Free trial content
Cookie Policy
Cookie Policy
Ingenta Connect website makes use of cookies so as to keep track of data that you have filled in. I am Happy with this Find out more