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Free Content Striatal Dopamine D1 receptors in narcolepsy: A PET study with [11C]NNC 756

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Abstract:

SUMMARY

We investigated dopamine D, receptors in the putamen and caudate nucleus with positron emission tomography in six patients with narcolepsy and five healthy controls using [11C]NNC 756 as ligand. The caudate-to-cerebellum and putamen-to-cerebellum ratios of [11C]NNC 756 were within normal limits in patients with narcolepsy. No evidence of increased D1, receptor binding in narcolepsy was found.

Keywords: NNC 756; dopamine; dopamine receptors; narcolepsy; positron emission tomography

Document Type: Regular Paper

DOI: http://dx.doi.org/10.1111/j.1365-2869.1996.00262.x

Affiliations: 1: Department of Neurology, University of Turku, Turku, Finland 2: Department of Neurology, University of Helsinki, Turku, Finland 3: Turku University PET-Centre, Radiopharmaceutical Chemistry Laboratory, Turku, Finland 4: Turku University PET-Centre, PET-Unit, University of Turku, Turku, Finland

Publication date: December 1, 1996

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