Topical Verapamil HCl, Topical Trifluoperazine, and Topical Magnesium Sulfate for the Treatment of Peyronie's Disease— A Placebo-Controlled Pilot Study

Authors: Fitch, William P.; Easterling, W. Jerry¹; Talbert, Robert L.²; Bordovsky, Michael J.³; Mosier, Michael⁴

Source: The Journal of Sexual Medicine, Volume 4, Number 2, March 2007 , pp. 477-484(8)

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Abstract:

Introduction.

Transdermal and intralesional verapamil has been reported to be useful in the treatment of Peyronie's Disease. This study evaluates a topically applied calcium channel blocker (verapamil hydrochloride 15% gel), a topically applied calmodulin blocker (trifluoperazine), and a topically applied weak calcium channel blocker (magnesium sulfate), each incorporated in a transdermal vehicle. Aim.

This pilot study was conducted to assess the efficacy of a 15% verapamil gel applied topically to the penile shaft twice daily for the treatment of Peyronie's Disease. Main Outcome Measure.

To assess improvement in curvature, plaque size, resolution of painful erections, and improvement in erection quality. Methods.

Two simultaneous, three armed, double blinded, placebo-controlled studies were conducted. After randomization into one of four groups, patients were treated for 3 months. At the end of 3 months' treatment using blinded drug, each patient was treated with open label topical verapamil for 6 months. The studies were completed after each patient had been treated and evaluated for 9 months after randomization. Results.

Fifty-seven patients were randomized. In total, 94.4% of patients treated for 9 months with topical verapamil experienced improvement in curvature with an average percent curvature change of 61.1% compared with 43.6% curvature improvement at 3 months. At 9 months the average percent plaque change was 84.7% compared with 55% at 3 months. Pain resolution at 9 months was 100% compared with 87.5% at 3 months. Patient perception of erection quality also increased at 9 months to 81.8% compared with 72.7% at 3 months. Conclusions.

Topical verapamil gel proved effective in eliminating pain on erection, decreasing the size of plaque, decreasing curvature, and improving erection quality in patients with Peyronie's Disease. Treatment results improved significantly after 9 months' treatment as compared with 3 months' treatment. Fitch WP III, Easterling WJ, Talbert RL, Bordovsky MJ, and Mosier M. Topical verapamil HCl, topical trifluoperazine, and topical magnesium sulfate for the treatment of Peyronie's Disease—A placebo-controlled pilot study. J Sex Med 2007;4:477-484.

Keywords: Peyronie's Disease; Calcium Channel Blocker; Topical Verapamil; Placebo

Document Type: Research article

DOI: http://dx.doi.org/10.1111/j.1743-6109.2006.00417.x

Affiliations: 1: PDL, San Antonio, TX, USA; 2: University of Texas Health Science Center at San Antonio, San Antonio, TX, USA; 3: Private Consultant, San Antonio, TX, USA; 4: Washburn University, Topeka, KS, USA

Publication date: 2007-03-01

Topical Verapamil HCl, Topical Trifluoperazine, and Topical Magnesium Sulfate for the Treatment of Peyronie's Disease— A Placebo-Controlled Pilot Study

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