Combined clotrimazole irrigation and depot therapy for canine nasal aspergillosis

Authors: Sissener; Bacon; Friend; Anderson; White

Source: The Journal of Small Animal Practice, Volume 47, Number 6, June 2006 , pp. 312-315(4)

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Abstract:

Objectives:

To evaluate the effect of short duration 1 per cent clotrimazole flush when combined with 1 per cent clotrimazole cream instilled into the frontal sinuses for the treatment of nasal aspergillosis in 14 dogs. Methods:

Fourteen dogs with clinical, radiological, serological and rhinoscopic findings consistent with nasal aspergillosis were treated by frontal sinus trephination and a short, five-minute flushing of 1 per cent topical clotrimazole solution followed by a 1 per cent clotrimazole cream instilled as a depot agent. Results:

Twelve of the 14 dogs (86 per cent) responded well to treatment and either had no clinical signs after treatment or had signs consistent with mild rhinitis during a minimum follow-up period of six months. Only one dog required multiple treatments. Treatment was well tolerated by all patients, with minimal complications. ClinicalSignificance:

This treatment compares favourably to previously published data using one-hour topical clotrimazole or enilconazole flushing treatment protocols. The treatment technique significantly reduced treatment time under anaesthesia.

Document Type: Research article

DOI: http://dx.doi.org/10.1111/j.1748-5827.2006.00017.x

Affiliations: 1: Dick White Referrals, Station Farm, London Road, Six Mile Bottom, Newmarket, Suffolk CB8 0UH

Publication date: 2006-06-01