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Changes in serum concentrations of tumor necrosis factor α and adhesion molecules in normal pregnant women and those with pregnancy-induced hypertension

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Abstract Aim: 

To study whether serum tumor necrosis factor α gene (TNFα) and adhesion molecule levels are indicators of the onset of pregnancy-induced hypertension (PIH), we compared levels of these molecules between normal pregnant women and PIH patients from the first to the third trimester. Methods: 

We serially measured serum concentrations of TNFα, soluble intercellular adhesion molecule-1 (sICAM-1), soluble E-selectin (sE-selectin), soluble vascular cell adhesion molecule-1 (sVCAM-1) and soluble P-selectin (sP-selectin) using enzyme immunoassay kits in 10 normal pregnant women and 10 pregnant women who developed PIH late in gestation. Results: 

Serum TNFα, sICAM-1 and sE-selectin levels in PIH affected women were significantly higher from the first trimester compared with those in normal pregnancy. sVCAM-1 and sP-selectin levels were not significantly changed. Conclusion: 

Serum TNFα, sE-selectin and sICAM-1 levels might be effective indicators of the onset of PIH.
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Keywords: (PIH); E-selectin; intercellular adhesion molecule-1 (ICAM-1; pregnancy; tumor necrosis factor α (TNFα)

Document Type: Research Article

Affiliations: Department of Obstetrics and Gynecology, Ehime University School of Medicine, Ehime, Japan

Publication date: 01 December 2003

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