Central Endogenous Vasopressin Induced by Central Salt-Loading Participates in Body Fluid Homeostasis through Modulatory Effects on Neurones of the Paraventricular Nucleus in Conscious Rats

Authors: Kato, K.¹; Kannan, H.²; Ohta, H.¹; Kemuriyama, T.¹; Maruyama, S.¹; Tandai-Hiruma, M.¹; Sato, Y.¹; Nakazato, M.³; Nishimori, T.⁴; Ishida, Y.⁵; Onaka, T.⁶; Nishida, Y.¹

Source: Journal of Neuroendocrinology, Volume 21, Number 11, November 2009 , pp. 921-934(14)

Publisher: Blackwell Publishing

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By this author: Kato, K. ; Kannan, H. ; Ohta, H. ; Kemuriyama, T. ; Maruyama, S. ; Tandai-Hiruma, M. ; Sato, Y. ; Nakazato, M. ; Nishimori, T. ; Ishida, Y. ; Onaka, T. ; Nishida, Y.

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Abstract:

Peripherally secreted arginine vasopressin (AVP) plays a role in controlling body fluid homeostasis, and central endogenous AVP acts as a neurotransmitter or neuromodulator. The limbic system, which appears to exert an inhibitory effect on the endocrine hypothalamus, is also innervated by fibres that contain AVP. We examined whether central endogenous AVP is also involved in the control of body fluid homeostasis. To explore this possibility, we examined neuronal activity in the paraventricular nucleus of the hypothalamus (PVN), periventricular parts of the PVN and limbic brain areas, as well as AVP mRNA expression in the PVN and the peripheral secretion of AVP after central salt-loading in rats that had been pretreated i.c.v. with the AVP V₁ receptor antagonist OPC-21268. Neuronal activity in the PVN evaluated in terms of Fos-like immunoreactivity (FLI), especially in the parvocellular subdivisions, was suppressed. On the other hand, FLI was enhanced in the lateral septum, the bed nucleus of the stria terminalis and the anterior hypothalamic area. Similarly, AVP mRNA expression was enhanced in the magnocellular subnucleus of the PVN, despite the lack of a significant difference in the peripheral AVP level between OPC-21268- and vehicle-pretreated groups. We recorded renal sympathetic nerve activity (RSNA) as sympathetic nerve outflow during central salt-loading. The suppression of RSNA was significantly attenuated by i.c.v. pretreatment with OPC-21268. These results suggest that the suppression of RSNA during central salt-loading might be the result of a decrease in neuronal activity in the parvocellular subdivisions of the PVN via the inhibitory action of central endogenous AVP. The parvocellular and magnocellular neurones in the PVN might show different responses to central salt-loading to maintain body fluid homeostasis as a result of the modulatory role of central endogenous AVP.

Keywords: central vasopressin; central salt-loading; vasopressin V1 receptor; paraventricular nucleus; body fluid homeostasis

Document Type: Research article

DOI: 10.1111/j.1365-2826.2009.01915.x

Affiliations: 1: Department of Physiology, National Defense Medical College, Saitama, Japan. 2: Department of Nutritional Science, Kyushu Women's University, Fukuoka, Japan. 3: Department of Internal Medicine, Faculty of Medicine, University of Miyazaki, Miyazaki, Japan. 4: Departmentof Neurobiology, Faculty of Medicine, University of Miyazaki, Miyazaki, Japan. 5: Department of Psychiatry, Faculty of Medicine, University of Miyazaki, Miyazaki, Japan. 6: Department of Physiology, Jichi Medical School, Tochigi, Japan.