IngentaConnect Smoking and relation to other risk factors in postmenopausal wome...

Authors: I. Os; A. Høieggen¹; A. Larsen²; P. M. Sandset³; S. Djurovic⁴; K. Berg⁴; A. Os⁵; K. Birkeland⁶; A. Westheim²

Source: Journal of Internal Medicine, Volume 253, Number 2, February 2003 , pp. 232-239(8)

Publisher: Blackwell Publishing

Abstract:

Os I, Høieggen A, Larsen A, Sandset PM, Djurovic S, Berg K, Os A, Birkeland K, Westheim A (University of Oslo; Ulleval University Hospital; and Aker University Hospital, Oslo, Norway). Smoking and relation to other risk factors in postmenopausal women with coronary artery disease, with particular reference to whole blood viscosity and bgr

-cell function. J Intern Med 2003; 253: 232–239. Objectives.

To investigate possible associations between smoking habits and other coronary risk factors in postmenopausal women with known coronary heart disease (CHD). Setting.

The study was conducted at a university clinic. Subjects.

A total of 118 postmenopausal women with CHD verified with angiography, consecutively recruited. Interventions.

Conventional treatment for CHD. The women were randomized to hormone replacement therapy (HRT) with transdermal 17- bgr

oestradiol and medroxyprogesterone acetate, or to a control group. Results.

Smokers were younger (P = 0.005), had lower body mass index (P = 0.04) and lipoprotein Lp(a) levels (P = 0.02) compared with nonsmokers. Smokers had reduced bgr

-cell function (homeostasis model assessment, P = 0.006), whereas whole blood viscosity (WBV) was higher at all shear rates. WBV was not affected by HRT over a 12-month period. Oestrone levels were higher in smokers. Conclusions.

Smoking adversely affects insulin secretion ( bgr

-cell function) and WBV in postmenopausal women with established CHD, which could be of importance as a mechanism for the increased risk of CHD in smokers. The importance of smoking as a risk factor, overrides the effect of Lp(a), which is lower in smokers compared with nonsmokers.

Keywords: age; bgr -cell function; coronary artery disease; oestrone; smoking; whole blood viscosity; women

Document Type: Research article

DOI: 10.1046/j.1365-2796.2003.01110.x

Affiliations: 1: Nephrology, 2: Cardiology, 3: Haematology, 4: Genetics, 5: Research Forum, Ulleval University Hospital and 6: Department of Endocrinology, Aker University Hospital, Oslo, Norway

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Smoking and relation to other risk factors in postmenopausal women with coronary artery disease, with particular reference to whole blood viscosity and -cell function