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Smoking and relation to other risk factors in postmenopausal women with coronary artery disease, with particular reference to whole blood viscosity and 
-cell function
Authors: I. Os; A. Høieggen1; A. Larsen2; P. M. Sandset3; S. Djurovic4; K. Berg4; A. Os5; K. Birkeland6; A. Westheim2
Source: Journal of Internal Medicine, Volume 253, Number 2, February 2003 , pp. 232-239(8)
Publisher: Wiley-Blackwell
Abstract:
. Os I, Høieggen A, Larsen A, Sandset PM, Djurovic S, Berg K, Os A, Birkeland K, Westheim A (University of Oslo; Ulleval University Hospital; and Aker University Hospital, Oslo, Norway). Smoking and relation to other risk factors in postmenopausal women with coronary artery disease, with particular reference to whole blood viscosity and-cell function. J Intern Med 2003; 253: 232–239. Objectives. To investigate possible associations between smoking habits and other coronary risk factors in postmenopausal women with known coronary heart disease (CHD). Setting. The study was conducted at a university clinic. Subjects. A total of 118 postmenopausal women with CHD verified with angiography, consecutively recruited. Interventions. Conventional treatment for CHD. The women were randomized to hormone replacement therapy (HRT) with transdermal 17- oestradiol and medroxyprogesterone acetate, or to a control group. Results. Smokers were younger (P = 0.005), had lower body mass index (P = 0.04) and lipoprotein Lp(a) levels (P = 0.02) compared with nonsmokers. Smokers had reduced -cell function (homeostasis model assessment, P = 0.006), whereas whole blood viscosity (WBV) was higher at all shear rates. WBV was not affected by HRT over a 12-month period. Oestrone levels were higher in smokers. Conclusions. Smoking adversely affects insulin secretion (-cell function) and WBV in postmenopausal women with established CHD, which could be of importance as a mechanism for the increased risk of CHD in smokers. The importance of smoking as a risk factor, overrides the effect of Lp(a), which is lower in smokers compared with nonsmokers.
Keywords:
age;
-cell function;
coronary artery disease;
oestrone;
smoking;
whole blood viscosity;
women
Document Type: Research article
DOI: http://dx.doi.org/10.1046/j.1365-2796.2003.01110.x
Affiliations: 1: Nephrology, 2: Cardiology, 3: Haematology, 4: Genetics, 5: Research Forum, Ulleval University Hospital and 6: Department of Endocrinology, Aker University Hospital, Oslo, Norway
Publication date: 2003-02-01
- In this: publication
- By this: publisher
- In this Subject: Internal Medicine
- By this author: I. Os ; A. Høieggen ; A. Larsen ; P. M. Sandset ; S. Djurovic ; K. Berg ; A. Os ; K. Birkeland ; A. Westheim
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