Chronic intoxication by doxycycline use for more than 12 years

Authors: Westermann, G. W.¹; Böhm, M.²; Bonsmann, G.²; Rahn, K. H.¹; Kisters, K.¹

Source: Journal of Internal Medicine, Volume 246, Number 6, December 1999 , pp. 591-592(2)

Buy & download fulltext article:

You have access to the full text article on a website external to ingentaconnect.

Please click here to view this article on Wiley Online Library.

You may be required to register and activate access on Wiley Online Library before you can obtain the full text. If you have any queries please visit Wiley Online Library

Abstract:

Westermann GW, Böhm M, Bonsmann G, Rahn KH, Kisters K (Westfälische Wilhelms-University, Münster, Germany). Chronic intoxication by doxycycline use for more than 12 years (Case Report). J Intern Med 1999; 246: 591-592.

We report the clinical case of a 12-years' intoxication by doxycycline. A patient with a depersonalization and derealization syndrome took 1 g doxycycline per day. In addition to hepatocellular necrosis with cholestasis, nephrotoxicity, leukopenia, anaemia and skin hyperpigmentation he suffered from hitherto unreported adverse cardiac events as intermittent supraventricular tachycardia and sporadic Wenckebach heart block. Despite a long period of self-medication these side-effects were reversible.

Keywords: adverse events; chronic intoxication; doxycycline; long-term treatment; side-effects

Document Type: Research article

DOI: http://dx.doi.org/10.1046/j.1365-2796.1999.00606.x

Affiliations: 1: Internal Medicine D and 2: Dermatology, Westfälische Wilhelms-University, Münster, Germany

Publication date: 1999-12-01