TY - ABST
AU - Housez, B.
AU - Cazaubiel, M.
AU - Vergara, C.
AU - Bard, J.‐M.
AU - Adam, A.
AU - Einerhand, A.
AU - Samuel, P.
TI - Evaluation of digestive tolerance of a soluble corn fibre
JO - Journal of Human Nutrition & Dietetics
PY - 2012-10-01T00:00:00///
VL - 25
IS - 5
SP - 488
EP - 496
N2 - Abstract
Background: To assess consumers’ acceptance of a new fibre, it is essential to evaluate its digestive tolerance after ingestion. We aimed to determine the tolerance of increasing dosages of Promitor™ Soluble
Gluco Fibre (SGF; Tate&Lyle, Hoffman Estates, IL, USA) up to 70 g fibre per day using a validated gastrointestinal composite score.
Methods: A composite score of gastrointestinal tolerance integrating gastrointestinal symptoms, stool frequency and consistency was applied.
To statistically validate this composite score, the gastrointestinal tolerance of inulin (10 g versus 20 g containing, respectively, 9 g versus 18 g of fibre) was assessed in 18 healthy volunteers in a randomised double‐blind placebo‐controlled cross‐over
study. Second, in a double‐blind placebo‐controlled cross‐over study with 20 healthy volunteers, the gastrointestinal tolerance of SGF in both acute and ‘spread over the day’ conditions of consumption was assessed.
Results: By contrast to 10 g,
20 g of inulin demonstrated a significant difference in composite score compared to placebo [P < 0.001, difference = 7.6; 95% confidence interval (CI) = 3.8–11.3]. These values were considered as reference during the second study. In acute
conditions, 40 g of SGF fibre was the highest (threshold) dose tested that indicates the digestive tolerance criteria (difference from placebo on the composite score <7.6 and upper limit of the 95% CI <11.3); this is twice the amount tolerated for inulin. In ‘spread over the
day’ conditions, 65 g of SGF fibre was the threshold dose (P < 0.001, difference = 6.5; 95% CI = 3.4–9.5).
Conclusions: The results of the present study demonstrate that 40 g of SGF fibre, when consumed as a single
dose, and 65 g of SGF fibre, when consumed in multiple‐doses, across the day are well‐tolerated by healthy volunteers.
UR - http://www.ingentaconnect.com/content/bsc/jhnd/2012/00000025/00000005/art00010
M3 - doi:10.1111/j.1365-277X.2012.01252.x
UR - http://dx.doi.org/10.1111/j.1365-277X.2012.01252.x