TY - ABST
AU - Park, H.
AU - Green, M. H.
AU - Shaffer, M. L.
TI - Association between serum retinol‐binding protein 4 concentrations and clinical indices in subjects with type 2 diabetes: a meta‐analysis
JO - Journal of Human Nutrition & Dietetics
PY - 2012-08-01T00:00:00///
VL - 25
IS - 4
SP - 300
EP - 310
How to cite this article Park H., Green M.H. & Shaffer M.L. (2012) Association between serum retinol‐binding protein 4 concentrations and clinical indices in subjects with type 2 diabetes: a meta‐analysis. J Hum Nutr
Diet. 25, 300–310 Abstract
Background: Retinol‐binding protein (RBP4) is an adipokine that may be important in type 2 diabetes. Previous studies have examined
the association between serum RBP4 concentrations and clinical indices in patients with type 2 diabetes, although the results obtained have been inconsistent. We conducted a meta‐analysis aiming to investigate the association between serum RBP4 concentrations and clinical indicators
of diabetes, renal function, metabolic syndrome and obesity in subjects with type 2 diabetes.
Methods: MEDLINE, EMBASE and CINAHL databases were searched from 2005 through November 2011, and the search identified 21 clinical variables from seven studies (total n = 1406).
For each variable, summary correlation coefficients (r
s) were estimated using a random‐effects meta‐analysis.
Results: None of the diabetes markers were correlated with serum RBP4 concentrations in subjects with type 2 diabetes, whereas all of
the renal function markers and many metabolic syndrome markers were significantly correlated. Summary correlation coefficients and 95% confidence intervals (CIs) were −0.36 (95% CI = −0.51 to −0.18) for creatinine clearance, −0.39 (95% CI = −0.44
to −0.33) for estimated glomerular filtration rate and 0.53 (95% CI = 0.30–0.71) for creatinine concentration. In addition, plasma triglyceride concentrations (r
s = 0.22; 95% CI = 0.11–0.32), plasma total cholesterol concentrations
s = 0.14 (95% CI = 0.05–0.23)] and low‐density lipoprotein cholesterol level (r
s = 0.14; 95% CI = 0.02–0.25) were positively correlated with serum RBP4 concentrations.
The results obtained in the present study suggest that serum RBP4 concentrations in patients with type 2 diabetes may be associated with diabetes‐related renal dysfunction and imbalances in lipid metabolism.
UR - http://www.ingentaconnect.com/content/bsc/jhnd/2012/00000025/00000004/art00002
M3 - doi:10.1111/j.1365-277X.2012.01262.x
UR - http://dx.doi.org/10.1111/j.1365-277X.2012.01262.x