Provider: Ingenta Connect
Database: Ingenta Connect
TY - ABST
AU - Shikany, J. M.
AU - Desmond, R.
AU - McCubrey, R.
AU - Allison, D. B.
TI - Meta‐analysis of studies of a specific delivery mode for a modified‐carbohydrate diet
JO - Journal of Human Nutrition & Dietetics
PY - 2011-12-01T00:00:00///
VL - 24
IS - 6
SP - 525
EP - 535
N2 - Abstract
Background: Obesity is highly prevalent throughout the world. Although modified‐carbohydrate diets (MCDs) comprise one popular approach, questions remain about their utility for weight loss. The objective of the
present study was to conduct a meta‐analysis of randomised controlled trials (RCTs) of a specific MCD compared with various control diets on weight loss.
Methods: Data from four RCTs (three obtained from the sponsor and one indentified through literature searches) were
included. Intent‐to‐treat analyses were conducted using multiple imputation to handle missing data, where possible. Because inter‐study heterogeneity was demonstrated with fixed‐effects meta‐analysis, a random‐effects meta‐analysis also was
Results: When considered separately, all four studies showed greater reduction in body weight with the MCD compared to control diets at 12‐week follow‐up; the results at 24 weeks (available for three of the studies) were not as consistent. Results
for body mass index (BMI) were similar. Greater reductions in waist circumference with the MCD were seen at either time point in only one study. When fixed‐effects meta‐analysis was applied, significantly greater reductions in weight, BMI and waist circumference with the MCD
at both 12 weeks (1.66 kg, 0.53 kg m–2 and 1.02 cm, respectively) and 24 weeks (1.20 kg, 0.43 kg m–2 and 0.69 cm, respectively) were evident. Random‐effects meta‐analysis revealed similar results;
however, the 24‐week difference for a reduction in waist circumference was no longer statistically significant.
Conclusions: Meta‐analysis of individual RCT results demonstrated consistent benefits of this MCD compared to control diets on weight loss up to 24 weeks
and waist circumference up to 12 weeks.
UR - http://www.ingentaconnect.com/content/bsc/jhnd/2011/00000024/00000006/art00002
M3 - doi:10.1111/j.1365-277X.2011.01203.x
UR - http://dx.doi.org/10.1111/j.1365-277X.2011.01203.x