TY - ABST
AU - Keld, R.
AU - Kinsey, L.
AU - Athwal, V.
AU - Lal, S.
TI - Pathogenesis, investigation and dietary and medical management of gastroparesis
JO - Journal of Human Nutrition & Dietetics
PY - 2011-10-01T00:00:00///
VL - 24
IS - 5
SP - 421
EP - 430
N2 - Abstract
Delayed gastric emptying (gastroparesis) is associated with significant morbidity and, occasionally, mortality; clinicians therefore need a high index of suspicion to avoid missing the diagnosis. This review discusses the aetiology,
diagnostic criteria and investigations pertinent to gastroparesis, and also critically reviews the evidence for nutritional and medical management strategies. Dietary manipulation plays a key role in management, and simple adjustment to meal routines and diets can lead to an improvement in
symptoms, whereas alternative feeding routes play an important role in more severe cases. The role of pharmaceutical intervention is less clear; prokinetics and antiemetics are often prescribed; however, evidence for their efficacy is lacking, whereas gastric electric stimulation has an evolving
role in the management of patients with symptoms refractory to medical therapies. The optimal treatment of gastroparesis would be to resolve symptoms and normalise gastric emptying times, and this may be achieved with future treatments that target the underlying pathology. For most patients
with mild to moderate disease, dietary intervention plays a central role in the management of gastroparesis.
UR - http://www.ingentaconnect.com/content/bsc/jhnd/2011/00000024/00000005/art00002
M3 - doi:10.1111/j.1365-277X.2011.01190.x
UR - http://dx.doi.org/10.1111/j.1365-277X.2011.01190.x